About the Hospital
At FGA Center we provide the special care and attention that the unique profile of each person requires. The aim is to identify those mechanisms that affect and effect the general biological state of the organism.
Functional Genomics in this multifactorial event is the necessary tool for the investigation of pathological as well as pathophysiological conditions due to the fact that all human illnesses are polygenetic.
Polygenetic mean that a large number of genes and their products are involved in the origin and development of any traits and/or disease. These genes are found in different gene loci and at the same time spread to different chromosomes of our genome.
This type of heredity pattern includes many possible phenotypes determined by interactions between multiple alleles. Hair color, skin color, eye color, height, weight, metabolic syndrome, etc., are all examples of multi-genetic characteristics.
A number of different genotypes result from polygenic characteristics consisting of various combinations of dominant and recessive alleles. Thus:
1. Individuals who inherit only dominant alleles will have a strong expression of the dominant phenotype.
2. People who do not inherit dominant alleles will have a strong expression of the residual phenotype.
3. Individuals who inherit different combinations of dominant and recessive alleles will exhibit different degrees of the intermediate phenotype.
The investigation through functional genomics includes the analysis and certification of Mononucleotide Polymorphisms (SNP's)of many genes involved and characterized for various pathological and pathological conditions and the analysis and qualification of Single Nucleotide Polymorphisms (SNP’s) of cytochrome P450 genes (mitochondria function).
Part of functional genomics is Biochemical Genetic – Metabolomics: the metabolites are closely related to the phenotypes of living organisms and provide information on biochemical activities of the cellular metabolism.
Based on the results of the biochemical genetics, of the specialized metabolites, of the gene single mononucleotide polymorphisms of numerous of genes involved and characterized for pathological and pathophysiological conditions and the analysis and qualification of Single Nucleotide Polymorphisms (SNP’s) of cytochrome P450 genes (mitochondria function), specialized and personalized nutritional supplements are recommended and administered.
The pandemic has demonstrated the critical importance of "well-being" in preventing disease and optimizing health. We know this because COVID 19 has disproportionately affected people suffering from chronic diseases and metabolic syndrome as well people who were experiencing unhealthy lifestyles.
Our goal is - and we want to make the necessary effort to make it happend- to give the mind and well-being of the body the scientific proximity and urgency they deserve.
No policy or innovative drug is as effective as "wellness" in minimizing disease and enhancing the duration and quality of life, when we know, for example, that the U.S. devotes 90% of healthcare costs (exceeding $3.8 trillion annually) to treating patients with chronic physical and mental conditions.
In this environment, personalized research is for us the only strategy, so that we can offer, through the synthesis - which for each person is unique - genetics, epigenetics, and also metabolites, the inspiration that will lead to a change in lifestyle, a better quality of life and ultimately to 'well-being'.
Atopic dermatitis and itchy skinAtopic Dermatitis is a chronic, inflammatory and often severely itchy skin disease, characterized by cycles of exacerbations and remission. The impact on quality of life can be significant. The pathogenesis of Atopic Dermatitis is not fully understood, but it is multifactorial and is associated with:
Dr. Eleftherios Georgakopoulos
Functional Genomics in this multifactorial event is the necessary tool for the investigation of metabolic syndrome.
Part of functional genomics is Biochemical Genetic – Metabolomics.
In Biochemical Genetic – Metabolomics, metabolites are closely related to the phenotypes of living organisms and provide information on biochemical activities that are reflecting as substrates and/or products of the cellular metabolism. It is worth pointing out here that metabolism is also known as the molecular phenotype of living organisms.
Biochemical Genetic – Metabolomics by studying and quantifying metabolites present in biological fluids, offers a direct picture of the system, providing useful information for understanding the processes that take place in the organism being analyzed.
For the investigation of atopic dermatitis and itchy skin, the following are used:
- Biochemical Genetic – Basic Panel of Metabolites (Metabolomics).
- Specialized Panel of Metabolic Syndrome Metabolites.
- Specialized Panel of 54 Single Mononucleotide Polymorphisms (SNP's) referred to different gene loci and genes, which have been identified and are related to atopic dermatitis and itchy skin.
- Specialized Panel of single mononucleotide polymorphisms (SNP's) of cytochrome P450 (CYP-SNP's) genes related to lipid metabolism and their peroxidation, where polyunsaturated fatty acids (PUFA's) are the important targets of free radicals and mitochondria.
The program includes the annual monitoring (4 visits) as well as the repetition of the Biochemical Genetics (Metabolomics) exams and the Specialized Panel of Metabolic Syndrome Metabolites 6 months after the initial examination.
Duration of initial visit: Collection of history and sampling 1 hour and Duration of Attendance: Annual